Solvent-free Biginelli Reaction Catalyzed to Synthesis of Biologically Active 3,4-dihydropyrimidin-2-(1H) –ones/thiones Derivatives
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Abstract:
A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives via one-pot three-component Biginelli condensation of arylaldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of Zn(SO4)2.7H2Oas anefficient, readily and inexpensive catalyst under solvent-free conditions have been studied. Thisprotocol has advantages such as readily available and non-toxic catalyst, short reaction times, goodto high yields, solvent-free conditions, facile reaction profiles, high atom-economy and simplework-up.
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Journal title
volume 13 issue 1
pages 45- 56
publication date 2019-01-01
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